7 Things You Should Know before Taking Antidepressants ...


7 Things You Should Know before Taking Antidepressants ...
7 Things You Should Know before Taking Antidepressants ...

There are some very important facts you need to know before taking antidepressants. Antidepressants are widely prescribed, and they can be very helpful. However, it is important to keep in mind that they are not always effective and they come with some serious side effects. Therefore, it is crucial that you have all the information before taking antidepressants.

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People take antidepressants with the expectation that their depression will be treated. However, before taking antidepressants, you should know that they are not effective for all people. In fact, a 2006 study conducted by the U.S. Government found that fewer than 50% of people become symptom free and many who do respond fall back into a depression even when continuing treatment. Also, antidepressants are only slightly more effective than a placebo for mild to moderate depression. Clearly, antidepressants are not 100% effective, and they are not something you should take thinking you will definitely feel better.


Theory of Chemical Imbalance

There is a long standing theory that depression results from a chemical imbalance in the brain. According to the theory, levels of serotonin in the brain become low, which means that an antidepressant's ability to increase serotonin levels should make a person feel better. The problem with this theory is that serotonin levels can’t be measured in the brain, and there is no knowledge of how antidepressants affect brain levels of serotonin. Also, some people with low serotonin levels don’t become depressed. Researchers have found that other factors, such as inflammation, increases in stress hormones, and nutrient deficiencies can contribute to depression. These other factors explain why antidepressants are not effective for everyone. There are multiple factors to consider when explaining the causes of depression.


Different Classes

Antidepressants are categorized into different classes according to the chemicals they affect, which include the neurotransmitters serotonin, norepinephrine, and dopamine. Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed and include Prozac. These work by preventing serotonin reuptake, which increases levels of serotonin. Cymbalta is in a different class of antidepressants that act on both serotonin and norepinephrine called serotonin and norepinephrine reuptake inhibitors. Another class is tricyclic antidepressants, which work on all three neurotransmitters. This is an older class that can be very effective, but is not prescribed as often because the side effects are worse and an overdose can be fatal. The last class is called MAOIs. This class of antidepressants is usually used as a last resort because the side effects can be very dangerous. All of these classes work in a slightly different way, which is why it is important to see a specialist when you are considering antidepressant medication.



Psychiatrists are doctors who specialize in psychiatric disorders including depression. They have extensive training in how to prescribe psychiatric medications like antidepressants. To achieve the best possible outcome, it is very important that you see a psychiatrist. Unfortunately, 80% of antidepressants are not prescribed by a psychiatrist, and of these 73% have not been given a proper psychiatric diagnosis. I realize that family doctors often prescribe antidepressants, but keep in mind that their psychiatric training is very limited. You will receive the most help from a psychiatrist.


Side Effects

Antidepressants do not come without side effects! The side effects can range from being mild to being very serious. Some of the more common side effects people experience include nausea, insomnia, anxiety, restlessness, dizziness, weight gain, headaches, and fatigue. Sometimes these side effects are severe enough that people discontinue the medication, which can result in other problems that I will talk about in the next point. The increased risk of suicidal thoughts or actions is a much more serious effect that should be taken very seriously. You will find warning labels on antidepressants or in the pamphlets that come with the prescription. These should not be ignored. Antidepressants should not be taken lightly, because the side effects can be life threatening.


Antidepressant Discontinuation Syndrome

When antidepressants are stopped abruptly after more than 6 weeks of use, very unpleasant symptoms can arise. People who don’t taper their medication down can experience flu-like symptoms, insomnia, nausea, imbalance, sensory disturbances, or hyper-arousal. These symptoms generally last 1 to 2 weeks, but going back on the medication will make the symptoms stop. If you are on an antidepressant and want to get off of it, you need to see your doctor to be given a proper tapering schedule.


Serotonin Syndrome

Although rare, antidepressants can cause serotonin syndrome. This occurs when you have too much serotonin in your body. The syndrome can be mild or very severe. Discontinuing the medication can make mild cases stop within a day, but more severe cases may need a medication to block the serotonin. The symptoms of serotonin syndrome include agitation, confusion, rapid heartbeat, loss of muscle coordination, shivering, headache, and goose bumps. More seriously, a person can have a fever, seizures, irregular heartbeat, and loss of consciousness. Serotonin syndrome requires medical care, so it is important to see a doctor if you suspect you are experiencing serotonin syndrome.

Depression is life changing and should always be treated. However, before taking antidepressants it is important to make sure they are the right course of action. Often, seeing a psychologist can be very helpful for depression, and even if you do choose medication, a therapist is always recommended so you can fix the underlying problem. What are your thoughts about antidepressants?

mayoclinic.com, mayoclinic.com, blog.doctoroz.com, helpguide.org, aafp.org

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Where Thoughts and Opinions Converge

Love this article! I've taken antidepressants for a long time, so unfortunately I know these things well. I think it's worth mentioning that some side effects might not be severe or as common but should still be taken into consideration. For instance, lot of medicines will lower the sex drive or sexual response...that might not be a problem for everyone, but it is for some.

#6 is seriously something to think about. Withdrawal is HORRIBLE.

And OMG #6 is no joke! One unfortunate problem I had with stopping Prozac the wrong way was suicidal thoughts and actions...basically, what caused me to go on the pills to begin with! I have bipolar disorder and I can honestly say that it was the grace of God and the medications I took that brought me back from the brink...some people thought I displayed weakness/wanting an easy fix/a lack of faith for taking them, but sometimes they are lifesavers if for no other reason that they help you think clearly enough to work through things in therapy. Thank you so much for writing this article.

I meant psychiatrist sorry, not psychiatric, but you probably got that anyways

Very useful and interesting article. I think when it comes to depression, the most effective way of treating it is probably medication and therapy. If possible, one shouldn't exclude the other. Of course, as you rightly say, it varies from person to person and some people will not respond well to medication. I've responded quite well to meds. I've been on Sertraline and now have been put on Cipralex (Escitalopram) instead, and it's much better for me, it treats both my anxiety and my depression, but I am going to therapy too. I think that the meds might make you feel better, but there will probably be some unresolved and painful issues that will only be healed through therapy. And definitely getting the meds prescribed through a psychiatric is essential. They will know how to advise you on what is best for you.

As much as I agree with this article, I do have to say- with the upmost confidence- that I don't know where I'd be if I didn't find my anti-depressant. It took a LONG time and yes, I had some of these awful symptoms.. But there are HUNDREDS of anti-depressants and you need to find the right one for you. Going on the one I'm on now only has one side effect- makes me drowsy at night. This is good, because I have insomnia so it forces me to sleep. Even though there are some horrible things that happen, more often than not the good outweighs the bad. That's why people go on them in the first place.

I wish I could've seen this article a few months ago before I started on antidepressants! I've already experienced most of these things, but they have passed with time. The transition period while your body is getting used to the medication sucks, but often (not always!) this will pass.

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